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Article Published In Vol.4 (May-June-2016)

Herbal Formulation development for Hypolipidemic and Anti-Obesity activity on Heartwood of Caesalpinia sappan Linn.

Pages : 409-420

Author : K.Mekala and R. Radha

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Medicinal plants have been shown to play a major role in treating hyperlipidemia and obesity and considering this, the present study was designed to develop a herbal capsule formulation on heartwood of Caesalpinia sappan for hypolipidemic and anti-obesity activity. The hydro alcoholic extract (1:1) on heartwood of Caesalpinia sappan was prepared by cold maceration method and formulated into a hard gelatin herbal capsule. The quantitative analysis of phytoconstituents especially of flavonoids and phenolic content present both in extract and formulated herbal capsule was estimated by HPLC method showed the presence of rutin, quercetin, gallic acid, ascorbic acid and tannic acid. Hydroalcoholic extract of Caesalpinia sappan (HECS) herbal capsule was evaluated for acute toxicity studies in albino wistar rats and showed no toxicity upto 2000mg/kg. In-vivo evaluation of high fat diet (HFD) induced obesity in rats was carried out for HECS herbal capsule .The studies showed HECS herbal capsule(200mg/kg and 400mg/kg) significantly reduced the elevated levels of body weight, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol, SGPT and SGOT and elevated the decrease level of HDL-cholesterol. These results suggest that, HECS capsule possess good hypolipidemic and anti-obesity activity, which may be due to its flavonoid, saponin and phenolic content.

Keywords: Caesalpinia sappan, Atherosclerosis, Herbal capsule formulation, High fat diet, Hypolipidemic and Anti-obesity activity




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