Article Published In Vol.9 (Nov-Dec 2021)

Pesticide from farm to Clinic: Possible Association between Pesticides and Diabetes Mellitus

Author : Aswin Sarath, John David, K. Krishnaveni and R. Sambath Kumar

Pesticides represent an increasingly widespread environmental exposure today and some of them have the potential to accumulate in human tissues either through direct exposure or through the food chain.There have been multiple findings linking diabetes and other metabolic problems to metabolic abnormalities, hyperglycemia, and oxidative stress in acute and chronic pesticide exposures. The major pesticides that are widely used include organophosphates (OP), organochlorines (OC), pyrethroids and carbamate (CB). The suppression of the enzyme acetylcholinesterase is the main mechanism of action of OP and CB (AChE) that results in signs and symptoms of excessive cholinergic stimulation. Exposure to OCs has been linked to the development of type 2 diabetes, which involves mitochondrial dysfunction, according to epidemiological research. Pyrethroid-induced oxidative stress may play a role in developing -cell pancreas dysfunction. In this report we performed a systematic review which aimed at highlighting the possible mechanisms that could lead to diabetes mellitus due long-term pesticide exposure.

Keywords: Diabetes, organophosphates (OP), organochlorines (OC), pyrethroids, carbamate (CB)