The Analgesic Effect of Ondansetron when Added to Lidocaine for Intravenous Regional Anesthesia

Abstract

Background: Intravenous regional anesthesia (Bier’sblock) is a simple, reliable, excellent technique for short open surgical procedures and for closed reduction of bony fracture.

Patients and methods: Thirty patients were enrolled in this study and randomly divided into two groups , Group A (n=15)received IVRA lidocaine 3 mg/kg 2% diluted with isotonic  saline to 0.5% concentration, Group B (n=15) received lidocaine 3mg/kg 2% plus Ondansetron diluted with isotonic saline to 0.5% concentration ,hemodynamic variables and VAS  were recorded before and after tourniquet inflation, tourniquet pain, post-operative pain and first analgesic requirement time till 6 hours postoperatively were recorded .

Results: No significant difference in demographic data. There was significant decrease of tourniquet pain and post-operative pain in Group B and relatively increase in mean time of first post-operative needing to analgesia by 1.6 hours  in Group B relative to Group A.

Conclusions: Adding 8 mg of Ondansetron to lidocaine in IVRAdecrease the tourniquet pain,  post-operative pain,  mean time for need of post-operative analgesia