IJMCR ISSN: 2321–3124
Articles can be submission online
We Follow Peer Review Process
Call for Papers: Sept-Oct 2017 Issue
Welcome to IJMCR
 

Article Published In Vol.2 (Nov-Dec-2014)

Assessment the Effect of Omega-3 Fatty Acid Supplementation in Sudanese patients with Sickle Cell Anemia; Khartoum, Sudan

Author : Babiker A. Mohammed, Alaaeddin Musaad. M. Elzubeir Tariq.E.Elmisbah Elmahdi Ahmed A.Addak and Magdi Mansoor Abdelfarag

Download PDF

Background: Sickle cell disease (SCD) is a group of genetic blood disorders characterized by a single point mutation in the sixth codon of the β-globin gene. Under low oxygen tension, the resultant abnormal hemoglobin S polymerizes and causes rigid and sickle-shaped red blood cells.
Objectives: This study aimed to assess the effect of omega-3 supplementation in patients with sickle cell anemia.
Subjects and methods: Seventy-eight SCD patients, who were undergoing regular follow-up at the outpatients SCD clinic in Ibn-Aoaf Pediatrics and Khartoum hospitals, were the main study group and 35 individuals were selected as control group. Patients recruited randomly were assigned to receive omega-3 fatty acid supplementation for at least two years. 5 ml of venous blood was collected from every individual into EDTA test tubes and used to determine complete blood count (CBC), electrophoresis and reticulocyte count.
Results: A significant difference in the Hb (g/dl) mean between the omega-3 group and the group free of omega-3 (P. value < 0.0001) was recorded. Also in total red blood cells count X 103C/M l, hematocrit and mean cell hemoglobin pg (P.value < 0.05) .No difference in levels between the study groups at mean cell volume / f l and mean cell hemoglobin concentration % (P. value < 0.05). Retics count and reticulocyte production index significant decrease in omega-3 group compared to control group (P.value < 0.0001).
Conclusions: These findings suggest that omega-3 fatty acids can be an effective, safe, and affordable therapy for sickle cell anemia.

Keywords: Sickle cell anemia, Omega-3 Fatty Acid, , Khartoum, Sudan.

 

Announcements

About IJMCR

All the persons belonging directly or indirectly to Microbiology, Biotechnology, Biochemistry, Virology, Environmental Sciences, Medical and Pharmaceutical Sciences, Food and Nutrition, Botany, Zoology, Mycology, Phycology and Agricultural Sciences.