Biomarkers of oxidative stress in newly diagnosed Tunisian type 2 diabetes mellitus
Pages : 241-246; DOI: https://doi.org/10.14741/ijmcr/v.9.3.7Download PDF
Background: Type 2 diabetes mellitus (DM), a metabolic disease that the percentage has increased in the world including Tunisia, is characterized by glycemic disorders. This disease is one of the main risk factors for cardiovascular diseases which are associated with activation of oxidative stress. Aim: The aims of this study were to evaluate the oxidative status in diabetic patients with and without cardiovascular diseases (CVD) and to determine the correlation between the different oxidative stress parameters.
Methods: Eighty newly diagnosed type 2 diabetes patients were recruited in this work. Forty diabetic patients without cardiovascular diseases (CVD), others forty diabetic patients with the history of cardiovascular diseases and twenty healthy controls patients were selected for this study.
Results: Our findings indicated that the plasma MDA levels, which is the most objective marker of intracellular oxidative stress levels, was significantly higher (p<0.05) in patients with both CVD and DM or with only DM in comparison to control patients. Plasma alpha tocopherol levels were decreased (p<0.001) in diabetic patients with CVD as compared to controls. The increase of homocysteine levels which may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction, and a significant decrease of SOD activity in diabetic patients with cardiovascular diseases compared with controls were also noted.
Conclusions: The obtained results revealed the crucial association between oxidative stress in Tunisian newly diagnosed diabetic patients and the development of risk factors like cardiovascular diseases.
Keywords: Oxidative stress, MDA, Alpha tocopherol, type 2 diabetes; cardiovascular diseases.