Article Published In Vol.5 (May-June-2017)

Estimation of Serum Interleukin-6 level as a Useful Marker for Clinical Severity of Sickle Cell Disease among Sudanese Patients

Author : Alaaeddin M.Elzubeir, Anna Alobied, Hala Halim, Mayadah Awad, Somia Elfaki, Maysoon Mohammed, Osman A. Saddig

Background: Sickle cell disease (SCD) is an inherited disease characterized by a complex and varied physiopathology and exhibits wide clinical diversity. SCA’s variability and pose significant management challenges to all medical staff
Objectives: We aimed in this study to correlate between serum interleukin-6 level and the clinical severity events of SCD in Sudanese Patients
Method: Case control study conducted on 133 patients with Sickle cell disease were collected and level of serum Il-6 were determined by ELISA and compared to 93 appearantly healthy individuals as Control group.
Result: There was significant association between elevation in serum IL-6 and development of complications in SCD, Chi squared (χ²) = 0.000 (P < 0.05).
Conclusion: These findings indicated that serum level of IL-6 may contribute to susceptibility to many crisis and may use as useful marker for early broadcasting tool for SCD crisis.

Keywords: Sickle Cell Disease, Severity, Serum IL-6, SCD Marker