DOI to all article
Articles can be submission online
We Follow Peer Review Process
Call for Papers for Current Issue
Welcome to IJMCR

Article Published In Vol.4 (Sept-Oct-2016)

Immunoinformatics Approach for Designing Epitope-Based Peptides Vaccine of L1 Major Capsid Protein against HPV Type 16

Pages : 879-896

Author : Sahar Suliman Mohamed, Marwa Mohamed Osman, Samah Mahmoud Sami, Hanaa Abdalla Elgailany, Maysaa Khalid Bushara, Hadeel Abdelrahman Hassan, Ghidaa Faisal Mustafa, Amna Idris Ali, Afra Abd Elhamid Fadl Alla, Alaa Abusufian Elkabashi & Mohamed Ahmed Salih

Download PDF

Human papilloma viruses (HPV) are small DNA, non-enveloped, double-stranded and closed circular viruses. There are more than 150 HPV identified types. Genital HPV types are categorized according to their epidemiologic association with cervical cancer to high and low risk types. The high risk type HPV 16 is the most common in the world. we aimed to design a universal peptide based vaccine against HPV type 16 virus using Immunoinformatics Approach through prediction of highly conserved T and B-cell epitopes from the most abundant and highly immunogenic protein (L1 major capsid protein) derived from HPV type 16 strains all over the world. All sequences of the L1 major capsid protein were retrieved from NCBI database. Potentially continuous B and T cell epitopes were predicted using tools from immune epitope data base analysis resource (IEDB-AR). The Allergenicity of predicted epitopes was analyzed by AllerTOP Tool and the coverage was determined throughout the worlds. The B cell epitope 243KSEV246 and T cell epitopes 363TRSTNMSLC371, 470YTFWEVNLK478, 260YIKMVSEPY268 and 236FTTLQANKS244 were suggested to become universal peptide based vaccine against HPV type 16. We hope to confirm our findings by adding complementary steps of both in vitro and in vivo studies to support this new universal predicted vaccine.

Keywords: Human papilloma viruses (HPV), Epitope, vaacine & In Silico.



All the persons belonging directly or indirectly to Microbiology, Biotechnology, Biochemistry, Virology, Environmental Sciences, Medical and Pharmaceutical Sciences, Food and Nutrition, Botany, Zoology, Mycology, Phycology and Agricultural Sciences.