Association of L-Selectin gene polymorphism with Clinical Severity of sickle Cell Disease among Sudanese Patients in Khartoum 2016

Abstract

Background: Sickle cell disease (SCD) is an inherited disease characterized by a complex and varied physiopathology and exhibits wide clinical diversity. SCA’s variability and pose significant management challenges to caregivers and physicians alike.

Objectives: We therefore introduced to correlate the clinical severity of SCD in Sudanese Patients and L.selectin gene polymorphisms.

Result: There was significant association between these gene polymorphisms and high expression of L-selectin by leukocytes, or the development of complications in SCD, Chi squared (χ²) = 0.000 (P < 0.05).

Conclusion: These findings indicated that the (P213S) polymorphism of L‐selectin gene may contribute to susceptibility to vasoocclusive crisis and more severe situation in the Sudanese patients with homozygous Sickle Cell disease.